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Efficacy of Standardized Celery Seed Extract in Patients with Chronic Painful  Inflammatory Conditions : A Clinical Study

Efficacy of Standardized Celery Seed Extract in Patients with Chronic Painful  Inflammatory Conditions : A Clinical Study

Celery seed extract is documented to be effective and safe. The extract has anti-inflammatory, analgesic and gastro-protective properties. Celery preparations have been used extensively since ancient times as natural therapies for managing acute and chronic painful or inflammatory conditions. Celery plant (Apium graveolens) is an indigenous plant from family Apiaceae. According to Ayurveda, the plant has a broad spectrum use as an aphrodisiac, anthelmintic, antispasmodic, carminative, diuretic, emmenagogue, laxative, sedative, stimulant, and toxin.
A single arm open-label, multi-centric study involving 50 doctors across India was carried out to investigate the efficacy of standardized celery seed extract tablets (Celery seed extract) for the treatment of chronic painful inflammatory conditions such as osteoarthritis and rheumatoid arthritis in adults.

The Enduring Role and Relevance of Cytology in the Diagnosis of Orbital and Eyelid Lesions

The Enduring Role and Relevance of Cytology in the Diagnosis of Orbital and Eyelid Lesions

A series of 150 fine-needle aspiration cytology (FNAC) from orbital and eyelid space- occupying lesions from years 2005 to 2015 were retrieved from records and reviewed. Corresponding histopathology was available in 112 cases, which showed concordance in 110 cases and discordance in 2 cases. Discordant cases were excluded. The male to female ratio was 1.5:1 with the mean age of 53 years. Our centre being a tertiary cancer centre had a total of only 6 benign lesions and 104 malignant lesions that were conclusively diagnosed. 73 of 104 malignant cases were of epithelial in origin; most commonly Squamous cell carcinoma followed by sebaceous carcinoma and basal cell carcinoma. Rhabdomyosarcoma was the most common non epithelial tumor followed by hematolymphoid malignancy. Four cases of orbital metastasis were identified with the primary tumor in breast, lung, prostate and thyroid. Immunocytochemistry (ICC) was performed manually on de stained wet fixed slides of 22 cases where other differential diagnosis was considered. These results confirm previous reports on the usefulness of FNA biopsy in diagnosing orbital and lid masses and emphasize the value of immunocytochemistry in tumor characterization.

Uncommon and Unexpected Gallbladder Lesions

Uncommon and Unexpected Gallbladder Lesions

Gallbladder carcinoma is a rare malignancy, usually seen in the sixth to seventh decade of life, with a strong female predominance. The prevalence varies in different parts of the world. In India, the Indian Council of Medical Research has found an incidence of 4.5/lakh population in males, and 10.1/lakh population in females in North India and 1.2/lakh population in South India respectively. Carcinoma often presents with signs and symptoms of cholecystitis and may not be suspected clinically and sometimes even in gross examination. Hence, it is essential that all gallbladders that are removed are thoroughly sampled. Associated cholelithiasis may be seen in 80% of cases. We had one case which presented as cholecystitis, and malignancy was not suspected clinically. These tumours are located in the body or fundus in 90% of the cases. On gross appearance they may be seen as nodular or polypoid masses, as a thickening of the wall or as a diffusely infiltrating tumour.

Dimensions of Ethical Issues in HIV/AIDS

Dimensions of Ethical Issues in HIV/AIDS

The UNAIDS guidelines (1996), calls for protective care and support for those infected with HIV, and also ensures social and cultural equality within the community without discrimination. The Ministry of Health of the Indian Government issued an administrative notification directing non-discriminatory access to all PLWHAs in all Central and State government health care institutions in 1992.

Osseous Hydatid Disease : A Rare Cause of Pathological Fracture

Osseous Hydatid Disease : A Rare Cause of Pathological Fracture

A 71-year-old man presented with pain and swelling of the left thigh. He had a history of a fall one month prior to presentation for which he had received an alternate medicine treatment. The X-ray showed an old fracture of the shaft of the femur with non–union. Routine laboratory investigations, chest x-ray and ultrasound abdomen were all within normal limits. The fracture was treated with limb reconstruction system (LRS) following which the patient a discharging sinus. LRS removal and fracture site debridement and intra medullary nailing with bone grafting was done after two weeks. Curetted tissue was sent for histopathology which comprised of membranous tissue bits with friable haemorrhagic material. Multiple sections studied showed viable and non–viable bony trabeculae, fibrin with areas of calcification and foreign body reaction. Multiple fragments of lamellated eosinophilic membranous tissue lined by innermost germinal layer with nuclei were seen